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MOLECULAR GENETIC
MARCO BARUCCA

Seat Scienze
A.A. 2016/2017
Credits 6
Hours 48
Period 1^ semestre
Language ENG
U-gov code SM04 3S092

Prerequisites

Knowledge of basal concepts of genetic and molecular biology.

Development of the course

5 CFU of lectures are planned as well as 1 CFU including practical laboratory (carried out individually or in small groups) and preparation and presentation of scientific papers related to the topics covered during the lectures.

Learning outcomes

Knowledge
Students will have acquired the fundamental concepts about the structure, function and evolution of eukaryotic genomes and genes and knowledge on the molecular genetics of the antibodies, tumors and on the principles and strategies for identifying gene-disease in humans.

Ability to apply the knowledge:
At the end of the course, students will be able to understand the molecular dynamics related to the evolution of genes and genomes (including in cancer cells). They should also be able to understand and design strategies for the identification of gene-disease in humans.

Soft skills
Laboratory activities performed in group as well as the preparation and presentation of reports on scientific articles will contribute to improve the autonomy level as well as communication skills also arising from work in groups.

Program

- The ground-breaking importance of genome projects; background and organization of the Human Genome Projects and genome projects for model organisms; Functional Genomics.
- Eukaryotic genomes: nuclear and mitochondrial. Organization, distribution and function of polypeptide-encoding genes, tandemly repeated noncoding DNA, interspersed repetitive noncoding DNA, transposable elements and retrotransposons.
- Evolution of gene structure and duplicated genes; evolution of chromosomes and genomes; comparative genomics; evolution of human populations.
- Identifying Human Disease Genes: principles and strategies.
- Cancer Genetics.
- Immuno molecular genetics of vertebrates.
- Strategies and methods in Molecular Genetics

Development of the examination

Methods for assessing learning outcomes:
Oral exam after registration in the reserved area.

Criteria for assessing learning outcomes: 
The oral examination is aimed at assessing the knowledge and understanding of Molecular Genetics and other subjects needed to resolve problems related to course objectives.

Criteria for measuring learning outcomes:
The final mark is assigned exclusively on the oral exam through questions at low, medium, and high difficulty related to three topics covered during the course. The exam is considered passed if the student demonstrates sufficient knowledge to each of the three topics. Laude is assigned if the student demonstrates full mastery of the subject.

Criteria for conferring final mark:
The final mark is assigned on the basis of the student's ability to provide answers that demonstrate mastery of the subject with clarity and with a relevant technical and scientific terminology. It will also evaluate the student's ability to link the topics covered during the course among themselves and with topics covered in other teachings already acquired by the student. 

Recommended reading

Tom Strachan e Andrew P. Read, “Genetica umana molecolare” Zanichelli – Bologna
Slides provided during the course.

Courses

• Biologia molecolare e applicata