Dipartimento di Scienze della Vita e dell'Ambiente - Guida degli insegnamenti (Syllabus)
Knowledge of physics, chemistry, biochemistry and general physiology
Lectures and e-learning.
The course provides the basic knowledge of the active ingredients in the most common drugs, their mechanism of action and to possible side effects. Will also be given notions about the most common drugs of abuse, natural origin, and the methods of analysis in biological samples
Ability to apply the knowledge:
The student at the end of the course will be able to:
Describe the most common active ingredients in the major drug classes.
Explain the mechanism of action of the major drug classes.
Describe the most common adverse effects and drug interactions of the major drug classes and individual active ingredients within these classes.
Describe the most common drugs of abuse and the most commonly used techniques for the detection of drugs in biological samples
Pharmacokinetics: routes of administration. absorption, distribution, metabolism and excretion. Transport across biological barriers.
Extrarenal and renal excretion of drugs. Pharmacokinetic parameters: bioavailability, apparent volume of distribution, plasma half-life, clearance.
Pharmacodynamics: receptors, mechanisms of action of the drugs: receptor sites, receptors and endogenous ligands. Concentration-response curves. Full agonists, partial agonists, inverse agonists, antagonists. Sensitization and tolerance to drugs. Therapeutic index. Principles of Pharmacogenetics and Pharmacogenomics.
Autonomic Nervous System Agents, adrenergics, cholinergics, dopaminergic agonists and antagonists. sedative-anxiolytics, general and local anesthetics, antidepressants, nonsteroidal anti-inflammatory drugs (NSAIDs). cardiac glycosides, ACE inhibitors. vasodilators, diuretics, calcium channel blockers, anticonvulsant, antiarrhythmic, penicillins, cephalosporins, tetracyclines, macrolides, aminoglycosides, fluoroquinolones, sulfonamides.
Most common drugs of abuse. Principles of most commonly used techniques for the detection of drugs and substances of abuse in biological samples
Methods for assessing learning outcomes
The exam consists in a multiple choice test, to be completed in 30 min.
Criteria for assessing learning outcomes:
The student has to recognize the most common active principles, identifying the therapeutic class of drugs, the mechanism of action, and side effects.
Criteria for measuring learning outcomes:
The test consists of 32 questions with four possible answers. For every question answered correctly is awarded a point, -0,2 points for a wrong answer.
Criteria for conferring final mark:
The final grade is attributed out of thirty. The exam is passed when the rating is equal or greater than 18. It is possible the award of full marks with honors (30 e lode) for a rating equal or greater than 30.
TITLE Le basi della Farmacologia
AUTHOR Clark, Finkel, Rey, Whalen